Most recent publication list and citation metrics

(67)   Lu M, Kanne CK, Reddington RC, Lezzar DL, Sheehan VA, Shevkoplyas SS (2021) “Concurrent assessment of deformability and adhesiveness of sickle red blood cells by measuring perfusion of an adhesive artificial microvascular network,” Frontiers in Physiology, 12:633080, DOI: 10.3389/fphys.2021.633080

(66)   Piety NZ, Stutz J, Yilmaz N, Xia H, Yoshida T, Shevkoplyas SS (2021) “Microfluidic capillary networks are more sensitive than ektacytometry to the decline of red blood cell deformability induced by storage,” Scientific Reports, 11(1):604, DOI: 10.1038/s41598-020-79710-3

(65)   Lu M, Shevkoplyas SS (2020) “Dynamics of shape recovery by stored red blood cells during washing at the single cell level,” Transfusion, 60(10):2370-2378, DOI: 10.1111/trf.15979

(64)   Robidoux J, Laforce-Lavoie A, Charette SJ, Shevkoplyas SS, Yoshida T, Lewin A, Brouard D (2020) “Development of a flow standard to enable highly reproducible measurements of deformability of stored red blood cells in a microfluidic device,” Transfusion, 60(5):1032-1041, DOI: 10.1111/trf.15770

(63)   Lu M, Rab MA, Shevkoplyas SS, Sheehan VA (2020) “Blood rheology biomarkers in sickle cell disease,” Experimental Biology and Medicine, 245(2):155-165, DOI: 10.1177/1535370219900494

(62)   Strachan BC, Xia H, Vörös E, Gifford SC, Shevkoplyas SS (2019) “Improved expansion of T cells in culture when isolated with an equipment-free, high-throughput, flow-through microfluidic module versus traditional density gradient centrifugation,” Cytotherapy, 21(2): 234-245, DOI: 10.1016/j.jcyt.2018.12.004

(61)   Lu M, Lezzar DL, Vörös E, Shevkoplyas SS (2019) “Traditional and emerging technologies for washing and volume reducing blood products,” Journal of Blood Medicine, 10: 37-46, DOI: 10.2147/JBM.S166316

(60)   Vörös E, Lu M, Lezzar D, Shevkoplyas SS (2018) “Centrifugation-free washing reduces buildup of potassium and free hemoglobin in washed red blood cells after the procedure,” American Journal of Hematology, 93(12): E389-E391, DOI: 10.1002/ajh.25277

(59)   Vörös E, Piety NZ, Strachan BC, Lu M, Shevkoplyas SS (2018) “Centrifugation-free washing: A novel approach for removing IgA from stored red blood cells,” American Journal of Hematology, 93(4): 518-526, DOI: 10.1002/ajh.25026

(58)   Hsu L, Nnodu OE, Brown BJ, Tluway F, King S, Dogara LG, Patil C, Shevkoplyas SS, Lettre G, Cooper RS, Gordeuk VR, Tayo BO (2018) “White Paper: Pathways to Progress in Newborn Screening for Sickle Cell Disease in Sub-Saharan Africa,” Journal of Tropical Diseases & Public Health, 6(2): 260, DOI: 10.4172/2329-891X.1000260

(57)   Gifford SC, Strachan BC, Xia H, Vörös E, Torabian K, Tomasino TA, Griffin GD, Lichtiger B, Aung FM, Shevkoplyas SS (2018) “A portable system for processing donated whole blood into high quality components without centrifugation,” PLoS One, 13(1): e0190827, DOI: 10.1371/journal.pone.0190827

(56)   Khanal G, Huynh RA, Torabian K, Xia H, Vörös E, Shevkoplyas SS (2018) “Towards bedside washing of stored red blood cells: a prototype of a simple apparatus based on microscale sedimentation in normal gravity,” Vox Sanguinis, 113(1): 31–39, DOI: 10.1111/vox.12605

(55)   Reinhart WH, Piety NZ, Shevkoplyas SS (2017) “Influence of feeding hematocrit and perfusion pressure on hematocrit reduction (Fåhraeus effect) in an artificial microvascular network,” Microcirculation, 24(8), DOI: 10.1111/micc.12396

(54)   Torabian K, Lezzar D, Piety NZ, George A, Shevkoplyas SS (2017) “Substituting Sodium Hydrosulfite with Sodium Metabisulfite Improves Long-Term Stability of a Distributable Paper-Based Test Kit for Point-of-Care Screening for Sickle Cell Anemia,” Biosensors (Basel), 7(3). pii: E39, DOI: 10.3390/bios7030039

(53)   Xia H, Khanal G, Strachan BC, Vörös E, Piety NZ, Gifford SC, Shevkoplyas SS (2017) “Washing in hypotonic saline reduces the fraction of irreversibly-damaged cells in stored blood: a proof-of-concept study,” Blood Transfusion, 15(5): 463-71; DOI: 10.2450/2017.0013-17

(52)   Piety NZ, Reinhart WH, Stutz J, Shevkoplyas SS (2017) “Optimal hematocrit in an artificial microvascular network,” Transfusion, 57(9): 2257-2266, DOI: 10.1111/trf.14213

(51)   Reinhart WH, Piety NZ, Shevkoplyas SS (2017) “Influence of red blood cell aggregation on perfusion of an artificial microvascular network,” Microcirculation, 24(5); DOI: 10.1111/micc.12317

(50)   Piety NZ, Shevkoplyas SS (2017) “Paper-Based Diagnostics: Rethinking Conventional Sickle Cell Screening to Improve Access to High-Quality Health Care in Resource-Limited Settings,” IEEE Pulse, 8(3):42-46; DOI: 10.1109/MPUL.2017.2678658

(49)   Piety NZ, George A, Serrano S, Lanzi MR, Patel PR, Noli MP, Kahan S, Nirenberg D, Camanda JF, Airewele G, Shevkoplyas SS (2017) “A Paper-Based Test for Screening Newborns for Sickle Cell Disease,” Scientific Reports, 7: 45488; DOI: 10.1038/srep45488

(48)   Xia H., Strachan BC, Gifford SC, Shevkoplyas SS (2016) “A high-throughput microfluidic approach for 1000-fold leukocyte reduction of platelet-rich plasma,” Scientific Reports, 6: 35943; DOI: 10.1038/srep35943

(47)   Piety NZ, Reinhart WH, Pourreau PH, Abidi R, Shevkoplyas SS (2016) “Shape matters: the effect of red blood cell shape on perfusion of an artificial microvascular network,” Transfusion, 56(4): 844-51

(46)   Khoory J, Estanislau J, Elkhal A, Lazaar A, Melhorn MI, Brodsky A, Illigens B, Hamachi I, Kurishita Y, Ivanov AR, Shevkoplyas S, Shapiro NI, Ghiran IC (2016) “Ligation of Glycophorin A Generates Reactive Oxygen Species Leading to Decreased Red Blood Cell Function,” PLoS One, 11(1): e0141206

(45)   Piety NZ, Yang X, Kanter J, Vignes SM, George A, Shevkoplyas SS (2016) “Validation of a low-cost paper-based screening test for sickle cell anemia,” PLoS One, 11(1): e0144901

(44)   Burns JM, Yoshida T, Dumont LJ, Yang X, Piety NZ, Shevkoplyas SS (2016) “Deterioration of red blood cell mechanical properties is reduced in anaerobic storage,” Blood Transfusion, 14(1): 80-8

(43)   Piety NZ, Gifford SC, Yang X, Shevkoplyas SS (2015) “Quantifying morphological heterogeneity: a study of more than 1 000 000 individual stored red blood cells,” Vox Sanguinis, 109(3): 221-30

(42)   Reinhart WH, Piety NZ, Deuel JW, Makhro A, Schulzki T, Bogdanov N, Goede JS, Bogdanova A, Abidi R, Shevkoplyas SS (2015) “Washing stored red blood cells in an albumin solution improves their morphological and hemorheological properties,” Transfusion, 55(8): 1872-81

(41)   Piety NZ, Yang X, Lezzar D, George A, Shevkoplyas SS (2015) “A rapid paper-based test for quantifying sickle hemoglobin in blood samples from patients with sickle cell disease,” American Journal of Hematology, 90(6): 478-82

(40)   Reinhart WH, Piety NZ, Goede JS, Shevkoplyas SS (2015) “Effect of osmolality on erythrocyte rheology and perfusion of an artificial microvascular network,” Microvascular Research, 98: 102-107

(39)   Kumar AA, Patton MR, Hennek JW, Lee SY, D’Alesio-Spina G, Yang X, Kanter J, Shevkoplyas SS, Brugnara C, Whitesides GM (2014) “Density-based separation in multiphase systems provides a simple method to identify sickle cell disease,” Proceedings of the National Academy of Sciences of the United States of America, 111(41): 14864-14869

(38)   Muroya T, Kannan L, Ghiran IC, Shevkoplyas SS, Paz Z, Tsokos M, Lucca JJ, Shapiro NI, Tsokos GC (2014) “C4D deposits on the surface of RBCs in trauma patients and interferes with their function,” Critical Care Medicine, 42(5): e364-e372

(37)   Yamaguchi E, Giannetti M, Van Houten M, Forouzan O, Shevkoplyas SS, Gaver DP (2014) “The unusual symmetric reopening effect induced by pulmonary surfactant,” Journal of Applied Physiology, 116(6): 635-644

(36)   Gifford SC, Spillane AM, Vignes SM, Shevkoplyas SS (2014) “Controlled incremental filtration: a simplified approach to design and fabrication of high-throughput microfluidic devices for selective enrichment of particles,” Lab on a Chip, 14(23): 4496-4505

(35)   Sosa JM, Nielsen ND, Vignes SM, Chen TG, Shevkoplyas SS (2014) “The relationship between red blood cell deformability metrics and perfusion of an artificial microvascular network,” Clinical Hemorheology and Microcirculation, 57(3): 275-289

(34)   Yang X, Piety NZ, Vignes SM, Benton MS, Kanter J, Shevkoplyas SS (2013) “Simple paper-based test for measuring blood hemoglobin concentration in resource-limited settings,” Clinical Chemistry, 59(10): 1506-1513

(33)   Ratnayaka SH, Hillburn TE, Forouzan O, Shevkoplyas SS, Khismatullin DB (2013) “PDMS well platform for culturing millimeter-size tumor spheroids,” Biotechnol Progress, 29(5): 1265-1269

(32)   Brown TP, Forouzan O, Shevkoplyas SS, Khismatullin DB (2013) “Histamine reduces GPIbα-mediated adhesion of platelets to TNF-α-activated vascular endothelium,” Thrombosis Research, 131(2): 150-157

(31)   Yang X, Kanter J, Piety NZ, Benton MS, Vignes SM, Shevkoplyas SS (2013) “A simple, rapid, low-cost diagnostic test for sickle cell disease,” Lab on a Chip, 13(8): 1464-1467

(30)   Forouzan O, Yang X, Sosa JM, Burns JM, Shevkoplyas SS (2012) “Spontaneous oscillations of capillary blood flow in artificial microvascular networks,” Microvascular Research, 84(2): 123-132

(29)   Burns JM, Yang X, Forouzan O, Sosa JM, Shevkoplyas SS (2012) “Artificial microvascular network: a new tool for measuring rheological properties of stored red blood cells,” Transfusion, 52(5): 1010-1023

(28)   Pinan-Lucarre B, Gabel CV, Reina CP, Hulme SE, Shevkoplyas SS, Slone RD, Xue J, Qiao Y, Weisberg S, Roodhouse K, Whitesides GM, Samuel A, Driscoll M (2012) “The core apoptotic executioner proteins CED-3 and CED-4 promote initiation of neuronal regeneration in Caenorhabditis elegans,” PLoS Biology, 10(5): e1001331

(27)   Shapiro ND,  Mirica KA, Soh S, Taran O, Phillips ST, Mace CR, Shevkoplyas SS, Whitesides GM (2012) “Measuring Binding of Protein to Gel-Bound Ligands Using Magnetic Levitation,” Journal of the American Chemical Society, 134(12): 5637-5646

(26)   Yang X, Forouzan O, Brown TP, Shevkoplyas SS (2012) “Integrated separation of blood plasma from whole blood for microfluidic paper-based analytical devices,” Lab on a Chip, 12(2): 274-280

(25)   Mirica KA, Ilievski F, Ellerbee AK, Shevkoplyas SS, Whitesides GM (2011) “Using Magnetic Levitation for Three Dimensional Self-Assembly,” Advanced Materials, 23(36): 4134-4140

(24)   Ghiran IC, Zeidel ML, Shevkoplyas SS, Burns JM, Tsokos GC, Kyttaris VC (2011) “Systemic lupus erythematosus serum deposits C4d on red blood cells, decreases red blood cell membrane deformability, and promotes nitric oxide production,” Arthritis & Rheumatism, 63(2): 503-512

(23)   Yang X, Forouzan O, Burns JM, Shevkoplyas SS (2011) “Traffic of leukocytes in microfluidic channels with rectangular and rounded cross-sections,” Lab on a Chip, 11(19): 3231-3240

(22)   Forouzan O, Burns JM, Robichaux JL, Murfee WL, Shevkoplyas SS (2011) “Passive recruitment of circulating leukocytes into capillary sprouts from existing capillaries in a microfluidic system,” Lab on a Chip, 11(11): 1924-1932

(21)   Glodek AM, Mirchev R, Golan DE,  Khoory JA, Burns JM, Shevkoplyas SS, Nicholson-Weller A, Ghiran IC (2010) “Ligation of complement receptor 1 increases erythrocyte membrane deformability,” Blood, 116(26): 6063-6071

(20)   Yoshida T, Shevkoplyas SS (2010) “Anaerobic storage of red blood cells,” Blood Transfusion, 8(4): 220-36

(19)   Hulme SE, Shevkoplyas SS, McGuigan AP, Apfeld J, Fontana W, Whitesides GM (2010) “Lifespan-on-a-Chip: microfluidic chambers for performing lifelong observation of C. elegans,” Lab on a Chip, 10(5): 589-597

(18)   Mirica KA, Shevkoplyas SS, Phillips ST, Gupta M, Whitesides GM (2009) “Measuring Densities of Solids and Liquids Using Magnetic Levitation: Fundamentals,” Journal of the American Chemical Society, 131(29): 10049-10058

(17)   Hulme SE, Shevkoplyas SS, Whitesides GM (2009) “Incorporation of prefabricated screw, pneumatic, and solenoid valves into microfluidic devices,” Lab on a Chip, 9(1): 79-86

(16)   Stan CA, Schneider GF, Shevkoplyas SS, Hashimoto M, Ibanescu M, Wiley BJ, Whitesides GM (2009) “A microfluidic apparatus for the study of ice nucleation in supercooled water drops,” Lab on a Chip, 9(16): 2293-2305

(15)   Mirica KA, Phillips ST, Shevkoplyas SS, Whitesides GM (2008) “Using magnetic levitation to distinguish atomic-level differences in chemical composition of polymers, and to monitor chemical reactions on solid supports,” Journal of the American Chemical Society, 130(52): 17678-17680

(14)   Hashimoto M, Shevkoplyas SS, Zasońska B, Szymborski T, Garstecki P, Whitesides GM (2008) “Formation of bubbles and droplets in parallel, coupled flow-focusing geometries,” Small, 4(10): 1795-1805

(13)   Hulme SE, Shevkoplyas SS, Samuel A (2008) “Microfluidics: streamlining discovery in worm biology,” Nature Methods, 5(7): 589-590

(12)   Wong AP, Gupta M, Shevkoplyas SS, Whitesides GM (2008) “Egg beater as centrifuge: isolating human blood plasma from whole blood in resource-poor settings,” Lab on a Chip, 8(12): 2032-2037

(11)   Hulme SE, DiLuzio WR, Shevkoplyas SS, Turner L, Mayer M, Berg HC, Whitesides GM (2008) “Using ratchets and sorters to fractionate motile cells of E. coli by length,” Lab on a Chip, 8(11): 1888-1895

(10)   Feinberg AW, Feigel A, Shevkoplyas SS, Sheehy S, Whitesides GM, Parker KK (2007) “Muscular thin films for building actuators and powering devices,” Science, 317(5843): 1366-1370

(9)     Shevkoplyas SS, Siegel AC, Westervelt RM, Prentiss MG, Whitesides GM (2007) “The force acting on a superparamagnetic bead due to an applied magnetic field,” Lab on a Chip, 7(10):1294-1302

(8)     Hulme SE, Shevkoplyas SS, Apfeld J, Fontana W, Whitesides GM (2007) “A microfabricated array of clamps for immobilizing and imaging C. elegans,” Lab on a Chip, 7(11):1515-1523

(7)     Fuerstman MJ, Lai A, Thurlow ME, Shevkoplyas SS, Stone HA, Whitesides GM (2007) “The pressure drop along rectangular microchannels containing bubbles,” Lab on a Chip, 7(11):1479-1489

(6)     Gifford SC, Derganc J, Shevkoplyas SS, Yoshida T, Bitensky MW (2006) “A detailed study of time-dependent changes in human red blood cells: from reticulocyte maturation to erythrocyte senescence,” British Journal of Haematology, 135(3): 395-404

(5)     Siegel AC, Shevkoplyas SS, Weibel DB, Bruzewicz D, Martinez AW, Whitesides GM (2006) “Co-fabrication of electromagnets and microfluidic systems in poly(dimethylsiloxane),” Angewandte Chemie (International ed. in English), 45(41): 6877-6882

(4)     Gifford SC, Yoshida T, Shevkoplyas SS, Bitensky MW (2006) “A high-resolution, double-labeling method for the study of in vivo red blood cell aging,” Transfusion, 46(4): 578-588

(3)     Shevkoplyas SS, Yoshida T, Gifford SC, Bitensky MW (2006) “Direct measurement of the impact of impaired erythrocyte deformability on microvascular network perfusion in a microfluidic device,” Lab on a Chip, 6(7): 914-920

(2)     Shevkoplyas SS, Yoshida T, Munn LL, Bitensky MW (2005) “Biomimetic autoseparation of leukocytes from whole blood in a microfluidic device,” Analytical Chemistry, 77(3): 933-937

(1)     Shevkoplyas SS, Gifford SC, Yoshida T, Bitensky MW (2003) “Prototype of an in vitro model of the microcirculation,” Microvascular Research, 65(2): 132-136